Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione), a powerful carotenoid pigment, has gathered attention for its potential health benefits, particularly in the realm of healthy aging. Found in marine life such as microalgae, salmon, and shrimp, astaxanthin is renowned for its potent antioxidant properties. Oxidative stress is a significant factor in aging, contributing to cellular damage and the onset of age-related diseases. By neutralizing free radicals, astaxanthin helps mitigate oxidative stress, which is crucial for maintaining cellular integrity and function.
Fig. 1 Benefits of astaxanthin in health and age-related conditions. (Bjørklund G, et al., 2022)
CD BioSciences specializes in astaxanthin supplement research and development services, helping clients develop supplement formulations that promote longevity and overall wellness.
How Do We Develop Astaxanthin Supplements as Geroprotectors?
High-quality ingredient sourcing
CD BioSciences sources astaxanthin from Phaffia yeast, Haematococcus, and chemical synthesis. We also conduct rigorous quality control assessments to ensure the purity and bioavailability of the raw materials, which are essential for anti-aging efficacy.
Customized formulation development
We can help clients develop various supplement formats, including soft gels, capsules, powders, and topical applications. Our team of experts employs various formulation techniques to enhance the bioavailability of astaxanthin. We also explore synergistic combinations with other longevity nutrients to target multiple anti-aging pathways.
Preclinical studies
We provide pharmacokinetic and functional studies to evaluate the potential of astaxanthin supplements in reducing oxidative stress, inflammation, and cellular senescence.
Evaluation of the Anti-Aging Effects of Astaxanthin Supplements
Using in vitro and in vivo experimental models, we provide comprehensive services to determine whether astaxanthin supplements exhibit anti-aging benefits.
Measurement of the antioxidant activity of astaxanthin supplements
We offer assays to measure the free radical scavenging activity of astaxanthin supplements and compare it with other known geroprotective agents.
Measurement of anti-lipid peroxidation activity of astaxanthin supplements
Given the importance of lipid peroxidation in aging and aging-related diseases, we help clients measure malondialdehyde (MDA) levels and other markers in tested samples to evaluate the efficacy of astaxanthin in preventing lipid peroxidation.
Assessment of anti-skin aging activity of astaxanthin supplements
We evaluate markers such as collagen content, elastin integrity, and matrix metalloproteinase (MMP) activity in skin cells to assist clients in determining if astaxanthin supplements can preserve skin elasticity and reduce wrinkle formation.
Evaluation of the anti-cognitive decline effects of astaxanthin supplements
To evaluate the effects of astaxanthin on age-related cognitive decline, we use behavioral tests such as the Morris water maze, Y-maze, and novel object recognition to assess spatial learning, memory, and executive function in aging animal models.
Evaluation of anti-inflammatory effects of astaxanthin supplements
Using ELISA assays, we help clients evaluate the anti-inflammatory potential of astaxanthin supplements by quantifying changes in key pro-inflammatory cytokines. In particular, the expression levels of cytokines such as TNF-α, IL-6, and IL-1β are measured to assess whether astaxanthin supplementation effectively attenuates inflammatory signaling associated with chronic inflammation and aging.
Evaluation of immune functions
To understand how astaxanthin influences immune health, we utilize flow cytometry and other techniques to analyze changes in immune cell populations (such as T cells and macrophages) following astaxanthin supplementation. We offer functional assays to evaluate the activity of immune cells in the presence of astaxanthin and how it may enhance or modulate immune responses in aging.
By combining high-quality ingredients, advanced extraction technologies, customized formulations, and comprehensive anti-aging efficacy evaluation, CD BioSciences helps clients develop astaxanthin supplements targeting key aging mechanisms, such as oxidative stress, inflammation, and cellular damage. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Bjørklund G, et al. The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions. Molecules, 2022, 27 (21): 7167.
- Ambati RR, et al. Astaxanthin: sources, extraction, stability, biological activities, and commercial applications--a review. Mar Drugs, 2014, 12 (1): 128-52.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
