Ergothioneine (EGT), a naturally occurring thiol compound, has garnered significant attention in recent years due to its potential health benefits, particularly its anti-aging properties. Produced by certain fungi and bacteria, ergothioneine is known for its powerful antioxidant properties and its role in cellular protection. It selectively accumulates in cells, particularly in high-stress environments such as the brain and liver. By neutralizing harmful reactive oxygen species (ROS), ergothioneine helps to mitigate oxidative damage to DNA, proteins, and lipids.
Fig. 1 Ergothioneine effects on oxidative stress-induced aging in a senescent cell. (Apparoo Y, et al., 2022)
At CD BioSciences, we specialize in ergothioneine supplement R&D services, providing innovative solutions to support healthy aging and mitigate aging-related oxidative stress.
Overview of Our Ergothioneine Supplement R&D Services
Ergothioneine bioproduction services
Our company uses engineered microbial fermentation to produce high-purity ergothioneine, which serves as a functional ingredient for the development of anti-aging supplements. We help clients assess the purity of ergothioneine using chromatographic and spectroscopic techniques, supporting quality assessment for downstream supplement formulation and research applications.
Formulation development services
Our company specializes in assisting clients in developing ergothioneine formulations optimized for supplements targeting healthy aging. Our experts provide comprehensive stability testing to assess the physical and chemical stability of ergothioneine formulations throughout their shelf life. In addition, we offer bioavailability studies to characterize the absorption and systemic exposure of ergothioneine, providing data to support formulation and delivery strategy development for anti-aging research.
Anti-Aging Efficacy Evaluation of Ergothioneine Supplements
At CD BioSciences, we provide a suite of services to assess the efficacy of ergothioneine supplements using established aging models, supporting formulation development and validation.
Oxidative stress analysis
We offer specialized services to evaluate the potential of ergothioneine supplements to mitigate oxidative stress, a key driver of cellular aging. Our assessments include measuring ROS levels, antioxidant enzyme activities, and markers of oxidative damage in cellular and animal models of aging.
Genome stability assessment
Our experts assess whether ergothioneine affects DNA integrity and repair mechanisms, which are crucial for maintaining genome stability and preventing aging-associated deterioration. We support measuring biomarkers of DNA damage and repair in aging models to elucidate the protective effects of ETG.
Analysis of epigenetic biomarkers of aging
We support analysis of how ergothioneine influences aging-related changes in DNA methylation and histone modifications, key epigenetic mechanisms that regulate gene expression during aging and contribute to functional decline.
Sirtuin pathway analysis
Sirtuins regulate cellular senescence and metabolic health. Our team measures the activation of sirtuins in the presence of ergothioneine, providing insights into its role in modulating aging-related signaling pathways.
CD BioSciences is dedicated to advancing the development of ergothioneine as a promising anti-aging supplement. Our expertise in bioproduction and formulation development allows us to provide high-quality ergothioneine supplement R&D services to support cellular health and longevity. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Apparoo Y, et al. Ergothioneine and its prospects as an anti-aging compound. Exp Gerontol, 2022, 170: 111982.
- Chen L, et al. Ergothioneine and its congeners: anti-aging mechanisms and pharmacophore biosynthesis. Protein Cell, 2024, 15 (3): 191-206.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
