Coenzyme Q10 (CoQ10) Supplement R&D Services

Coenzyme Q10 (CoQ10) acts as a powerful antioxidant, helping to neutralize free radicals and reduce oxidative stress, which is a significant factor in the aging process. One of the primary functions of CoQ10 is its role in the electron transport chain, where it facilitates the production of adenosine triphosphate (ATP), the energy currency of the cell. As people age, the natural levels of CoQ10 in the body decline, leading to decreased mitochondrial function and increased susceptibility to age-related diseases. Supplementing with CoQ10 may help restore optimal levels, promoting cellular health and longevity.

Fig. 1 Pictorial representation of CoQ10 as a health supplement. (Shukla S and Dubey KK, 2018)

CD BioSciences is committed to providing innovative synthesis, formulation, and anti-aging efficacy evaluation services to advance the research and development of CoQ10 supplements.

Overview of Our CoQ10 Supplement R&D Services

CoQ10 synthesis and formulation development services

Our company provides chemical, semi-synthetic, and biosynthetic methods to produce high-purity CoQ10. We support the development of CoQ10 supplement formulations with improved stability, absorption, and bioavailability, providing technical data to inform formulation design in anti-aging research. We also conduct rigorous stability studies to assess the integrity of CoQ10 under various conditions, ensuring a long shelf life and consistent potency.

Preclinical studies

We offer safety evaluation services to characterize the safety profile of CoQ10 supplements, supporting informed formulation and usage decisions in anti-aging research. Our services include chronic toxicity assessment and dosing studies, as well as pharmacokinetic evaluations in which key parameters such as peak plasma concentration (C_max), time to reach peak concentration (T_max), and elimination half-life (t_1/2) are determined.

Evaluation of the Anti-Aging Effects of CoQ10 Supplements

• Evaluation of CoQ10 supplements on age-related mitochondrial dysfunction. We offer testing services to evaluate the effects of CoQ10 supplements on mitochondrial function in aging. Using senescent cells and aging animal models, we help clients measure ATP production, mitochondrial membrane potential, and respiratory chain activity to assess the role of CoQ10 supplements in sustaining cellular energy metabolism during aging.
• Evaluation of CoQ10 supplements on age-related oxidative stress. Our experts assist clients in assessing the antioxidant potential of CoQ10 supplements through the measurement of oxidative stress biomarkers and antioxidant defense parameters, including malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) activity. Our services provide insights into the role of CoQ10 supplements in neutralizing reactive oxygen species (ROS) and protecting cells from oxidative damage.
• Evaluation of CoQ10 supplements on skin aging. We conduct specialized studies to evaluate the protective effects of CoQ10 supplements against skin aging. Using aging models, our experts support clients in assessing the impact of CoQ10 supplements on collagen synthesis, elastin integrity, and dermal fibroblast function, as well as their ability to reduce wrinkle formation and improve skin hydration
• Evaluation of CoQ10 supplements on longevity-related molecular pathways. We investigate the potential effects of CoQ10 supplements on longevity-related molecular pathways, with a focus on the modulation of SIRT1 and AMPK signaling, providing comprehensive analyses of its anti-aging potential.

CD BioSciences offers a range of R&D services to help clients develop high-quality CoQ10 supplements that can improve mitochondrial health, reduce oxidative stress, and promote healthy aging. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Shukla S, Dubey KK. CoQ10, a super-vitamin: review on application and biosynthesis. 3 Biotech, 2018, 8 (5): 249.