Anti-Glycation Skincare R&D Services

Glycation is a biochemical reaction in which sugar molecules, usually glucose or fructose, bind non-enzymatically to proteins or lipids. This process leads to the formation of advanced glycation end-products (AGEs), which can hinder the function and structural integrity of essential proteins, such as collagen and elastin, within the skin. The accumulation of AGEs is associated with various signs of skin aging, including loss of elasticity, fine lines, uneven tone, and a dull complexion.

Fig. 1 AGE formation. (Song Q, et al., 2021)

Research indicates that AGEs contribute to the signs of aging and may also exacerbate inflammatory processes, leading to further skin deterioration. CD BioSciences provides specialized R&D services support the development of anti-glycation skincare products that mitigate skin aging.

How Do We Develop Anti-Glycation Skincare?

Anti-glycation ingredient selection

We help clients select the right ingredients that demonstrate potent inhibitory effects on glycation or effectively counteract the damage caused by AGEs. Our experts consider the following categories of ingredients:

• Glycation inhibitors. CD BioSciences offers services to identify and evaluate the efficacy of various glycation inhibitors, such as N-acetylglucosamine (NAG) and glycyrrhizin. We help clients evaluate how different glycation inhibitors perform in combination with other active ingredients for optimal anti-aging efficacy.
• Anti-glycation peptides. Certain peptides, such as carnosine, have been shown to possess anti-glycation properties, promoting aging skin repair and regeneration. CD BioSciences specializes in designing custom peptides tailored to specific client needs. We utilize advanced biochemistry techniques to develop peptides aimed at reducing glycation damage and promoting anti-aging benefits. that target anti-glycation and anti-aging. We also conduct rigorous bioactivity testing to evaluate the effects of peptide formulations in inhibiting glycation and promoting skin rejuvenation.

Formulation development services

CD BioSciences applies a range of formulation strategies to enhance anti-glycation performance. Advanced delivery technologies, such as microencapsulation and nanoemulsions, are used to improve the stability and bioavailability of active ingredients, thereby supporting their anti-glycation and anti-aging effects.

Anti-glycation efficacy evaluation services

Our company helps clients measure the formation of AGEs in treated and untreated samples, providing quantitative results of the activity of anti-glycation skincare formulations. We offer in vitro biochemical assays, such as BSA-glucose and BSA-methylglyoxal systems, to quantify AGE inhibition. We use fluorescence-based detection methods and LC-MS/MS quantification to measure AGE accumulation. Our experts use human dermal fibroblasts under glycation stress to assess the protective effects of anti-glycation skincare on skin structure. We also provide ex vivo human skin explants for more physiologically relevant testing of anti-glycation skincare formulations.

Anti-aging efficacy evaluation services

Since glycation often interacts with oxidative stress and photoaging, evaluating anti-aging activity is critical for assessing the benefits of skincare formulations. Our company integrates molecular and functional approaches in anti-aging activity analysis services. Using 3D reconstructed human skin equivalents and ex vivo human skin models, we further assess histological and biochemical endpoints, such as collagen and elastin integrity, MMP expression, and wrinkle or pigmentation markers.

CD BioSciences provides a comprehensive suite of services supporting the development of anti-glycation skincare products, with expertise in glycation inhibitors and anti-glycation peptides. Our expertise in ingredient selection, formulation development, and anti-glycation and anti-aging efficacy evaluation services empowers clients to develop innovative skincare that mitigates skin aging. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Song Q, et al. Novel advances in inhibiting advanced glycation end product formation using natural compounds. Biomed Pharmacother, 2021, 140: 111750.