The liver, a vital metabolic organ, undergoes significant functional and structural decline with age, increasing vulnerability to various liver diseases. This age-related hepatic dysfunction is a complex process involving decreased hepatocyte proliferation and regenerative capacity, increased oxidative stress and inflammation, and progressive fibrosis. In vitro and in vivo models reflecting the multifaceted nature of liver aging are crucial to effectively study and counteract these detrimental changes.
Fig. 1 Schematic representation of the aging liver. (Hunt NJ, et al., 2019)
CD BioSciences specializes in customizing liver aging models, providing researchers with the necessary tools to investigate the mechanisms of liver aging and develop effective therapeutic interventions.
What Liver Aging Models Can We Customize?
Our company helps clients customize liver aging models tailored to diverse research needs. Our expertise encompasses both in vitro and in vivo systems, offering unique advantages for specific research questions.
In vitro models of hepatic senescence
CD BioSciences develops customized models using primary human hepatocytes or hepatic stellate cells (HSCs). We induce senescence through various methods, including exposure to senescence-inducing agents (e.g., D-galactose, oxidative stress) or genetic manipulation. Our models allow clients to assess the effects of age-related changes on cellular function, gene expression, and responses to therapeutic agents.
Animal models of liver aging
- Naturally and accelerated aging models. We provide naturally aging animal models, such as aged rodents, that reflect the physiological changes occurring in the liver over time. Our models closely mimic human conditions and are essential for studying aging-related liver diseases and evaluating the effects of new therapeutics. We also offer senescence-accelerated mice (SAM) to assist clients in studying the intrinsic mechanisms of liver aging.
- Mimetic aging models. These models mimic specific aspects of aging-related changes in the liver. Our company helps clients develop D-galactose-induced liver aging models to induce oxidative stress and accelerate aging processes within the liver.
- Transgenic aging models. We develop models with targeted gene knockouts or overexpressions, allowing investigation of the role of specific genes in age-related liver dysfunction. Our models allow targeted investigation of specific molecular pathways involved in liver aging.
Features of Our Custom Liver Aging Models
CD BioSciences prides itself on offering liver aging models with several key features:
- Customization. We customize models to align with specific research objectives by selecting appropriate cell types, inducing liver aging, or integrating genetic modifications.
- High relevance. Our models closely mimic the physiological changes associated with human liver aging, providing clients with reliable data. Our rigorous protocols ensure high reproducibility and consistency of liver aging models.
- Comprehensive characterization. We support a thorough characterization of the models, including detailed phenotypic and molecular analyses.
CD BioSciences is dedicated to enhancing the understanding of liver aging through customized models. By providing diverse in vitro and in vivo options, our company empowers clients to explore the complex processes of liver aging and develop effective therapeutic strategies. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Zhao Y, et al. Understanding the Unique Microenvironment in the Aging Liver. Front Med (Lausanne), 2022, 9: 842024.
- Hunt NJ, et al. Hallmarks of Aging in the Liver. Comput Struct Biotechnol J, 2019, 17: 1151-1161.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
