Numerous studies have shown that changes in DNA methylation dynamics during aging proceed in a specific direction. Individuals at different stages of life have distinct DNA methylation patterns that change in a tissue-specific manner during aging. DNA methylation plays an important role in various age-related biological processes, including aging and related diseases, which is the most potential biomarker for monitoring aging, exploring longevity, and predicting longevity.
Fig. 1 Schematics of DNA methylation patterns in early life and aging. (Smith EM, et al., 2020)
However, most of the dynamic mechanisms of DNA methylation remain unexplored. CD BioSciences provides various DNA methylation analysis services to identify and characterize DNA methylation changes during aging and age-related diseases.
Our Analysis Services for DNA Methylation in Aging
We provide comprehensive analytical services to address the dynamics of DNA methylation during aging and related diseases, including analysis of genome-wide DNA methylation levels, and expanding the field of DNA methylation analysis through array and sequencing technologies.
Targeted Bisulfite Sequencing Services for Aging Research
Our targeted bisulfite sequencing services provide high-resolution, targeted analysis of DNA methylation. Using advanced sequencing technologies, we offer customized solutions for the analysis of specific genomic regions, enabling researchers to gain insights into methylation patterns at a targeted level. Our clients use this technique for examining age-dependent DNA methylation patterns, developing epigenetic clocks, and discovering aging biomarkers.
Reduced Representation Bisulfite Sequencing (RRBS) Services for Aging Research
With our reduced representation bisulfite sequencing (RRBS) services, clients can obtain the genome's in-depth methylation profiles of CpG-rich regions. Our cost-effective approach allows for efficient coverage of important genomic loci, making it an invaluable tool for studying the complex interplay between DNA methylation dynamics and aging-related processes.
Whole Genome Bisulfite Sequencing (WGBS) Services for Aging Research
CD BioSciences provides WGBS to identify and analyze DNA methylation on a genome-wide scale efficiently. We provide all genome-wide bisulfite sequencing data and plots, including methylation heatmaps, CpG methylation distributions, DNA methylation average reads, and more. Furthermore, our clients can unravel the intricate epigenetic mechanisms underlying the aging process by leveraging our expertise in WGBS data analysis.
Methylation-Specific PCR Services for Aging Research
Our methylation-specific PCR (MSP) services enable the targeted amplification and analysis of methylated DNA sequences. Our high-specificity method allows for the quantification of methylation levels at specific loci, offering valuable data for understanding age-related methylation patterns.
Global DNA 5mC Measurement Services for Aging Research
At CD BioSciences, we excel in global DNA 5mC measurement services, utilizing methodologies to quantitatively assess the levels of 5-methylcytosine (5mC) across the entire genome. Our services involve the assessment of 5mC levels in specific age-related genes or genomic regions, providing valuable insights into the epigenetic mechanisms of aging.
Global DNA 5hmC Measurement Services for Aging Research
We employ multifaceted techniques for global DNA 5hmC measurement, offering highly sensitive and specific assays to measure 5hmC levels in diverse sample types quantitatively. By examining the distribution and abundance of 5hmC marks, our clients can gain insights into the epigenetic changes associated with aging and age-related diseases.
Our Features and Advantages
- High-throughput analysis technologies
We can provide methylome analysis at the scale of many biological samples, providing the greatest possibility for assessing DNA dynamics in the aging environment.
- Multiple bioinformatics tools
After data acquisition, we provide free technical support for bioinformatic analysis of DNA methylation data for the identification and characterization of methylation marks.
Applications of DNA Methylation Dynamics Analysis in Aging Studies
- As a lifespan biomarker, it has the potential lifespan prediction ability by analyzing DNA methylation changes to assess the effect of the aging process.
- As a biomarker for age-related diseases, it becomes a measurable indicator to predict or evaluate treatment disease states, helping the development of personalized medicine.
CD BioSciences has rich experience in dynamic analysis of DNA methylation and a high-throughput technology platform. Combining experience and technology, we are confident in delivering a high-quality service and guaranteeing your complete satisfaction. Especially in genome-wide analysis, we can provide cost-effective and comprehensive sequencing services. If you need related services and have any questions about our services, please contact us.
Reference
- Ciccarone F, et al. DNA methylation dynamics in aging: how far are we from understanding the mechanisms? Mech Ageing Dev, 2018, 174: 33-17.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
