Immunogenomic services are essential to the study of aging by providing crucial insights into the intricate interplay between the immune system and the aging process. These services incorporate immunology and genomics to investigate how genetic variations affect immune responses and influence health outcomes in older adults. At CD BioSciences, we offer immunogenomic services to shed light on the complex relationship between the immune system and aging.
Overview of Our Immunogenomic Services
Systems approach for aging research
We integrate immunogenomic services with systems biology approaches, such as network analysis and computational modeling, to explore the complex interactions between immune-related genes, pathways, and cellular processes involved in aging. By analyzing large-scale datasets generated by immunogenomic services, we can provide a holistic understanding of immune system dynamics during aging.
Genetic variations and immune response in aging
We provide immunogenomic services to analyze genetic variations, such as single nucleotide polymorphisms (SNPs), in genes involved in immune regulation. By studying these genetic variations, we can uncover associations between specific genetic variants and altered immune responses in aging populations.
Our Workflow of Immunogenomic Services
- Study design and sample collection
The first step in the workflow is to design the study and plan the sample collection. Depending on the customer's research objectives, we help to select appropriate study cohorts (e.g., healthy older adults, and individuals with age-related diseases), and determine the sample size. Sample collection protocols are established, ensuring proper methods for obtaining blood, tissue, or other relevant samples.
- Sample processing and immune cell isolation
Once the samples are collected, we isolate immune cells of interest such as peripheral blood mononuclear cells (PBMCs), T cells, B cells, or myeloid cells.
- Genomic sequencing
We sequence the DNA from the samples to identify genetic variations, including single nucleotide polymorphisms (SNPs), insertions, deletions, and structural variations that may be associated with aging and immune function.
- Immune profiling
We comprehensively analyze the immune system's composition and function by techniques such as flow cytometry, mass cytometry, and single-cell RNA sequencing. These methods allow us to identify changes in immune cell subsets, functional alterations, and immune signatures associated with aging.
- Data integration
We integrate genomic and immune profiling data to identify genetic variants associated with changes in immune function during aging. This may involve bioinformatics tools, statistical analysis, and pathway mapping to understand the molecular pathways involved.
Techniques Tools for Immunogenomic Services
We offer precise and dependable immunogenomic services using various techniques. Our analysis of genetic variations, including SNPs, insertions, deletions, and structural variations linked with both aging and immune function, is conducted through advanced sequencing technologies like next-generation sequencing (NGS). Additionally, we examine changes in immune cell composition, activation markers, and functional states linked with aging through flow cytometry and mass cytometry.
At CD BioSciences, we provide a wide range of immunogenomic services including immune profiling, genetic variation analysis, and systematic data analyses. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
