Shortest Telomere Measurement Services

The shortest telomere is an important influencing factor for human aging and many related diseases, and the shortest telomeres can lead to a DNA damage response and trigger a range of aging phenotypes. Therefore, information on the measurement of the shortest telomeres can assist in the study of human longevity and disease. CD BioSciences can provide the shortest telomere measurement service to better understand information on telomere-related aging and disease.

Introduction of the Shortest Telomere Measurement

The shortest telomeres are associated with genetic alterations that may contribute to cellular senescence, and their percentage can be used as a predictor of lifespan or as a biomarker for related diseases. Several internal and external factors such as environment, stress, and disease may cause rapid telomere shortening. However, many methods have been developed to measure telomere length, such as TRF, qPCR, Q-FISH, etc., but they are not able to quantify the shortest telomere length.

Overview of Our Shortest Telomere Measurement Services

CD BioSciences provides a method for determining the shortest telomere length, which allows for more efficient and accurate detection of the shortest telomeres. We provide all data relating to the results of the study, which are available for publication in the article.

Herein, we provide the shortest telomere assays, combined with software to image the results directly, providing our customers with efficient, concise, and accurate measurements. We can detect telomeres in the <1-18 kb range for applications in the aging process, disease progression, and telomere-related processes, including human and animal samples.

• Measurement of the shortest telomeres
  Our specific assay will link the sample genome and telomere region, design primers to ligate the DNA, perform PCR amplification, isolate the product and perform gel electrophoresis, and detect the amplified telomeres by blotting analysis.
• Software analysis
  We provide software that automatically detects sample images and performs statistical analysis to calculate the mean telomere length, the shortest telomere length as well as its percentage and other relevant data.

Technical Route for Measuring Shortest Telomeres

CD BioSciences' services help our clients to study changes in the shortest telomeres during aging-related processes, providing information on telomere dynamics. Our technical solutions provide resolution in the detection of the shortest telomeres, with low sample requirements and no restrictions on sample format.

Applications of Shortest Telomere Measurement

• We apply the shortest telomere measurement to detect the dynamic process of telomere change during normal human aging.
• We apply the shortest telomere measurement to the study of the progression of telomere-related diseases such as cancer, exploring the relationship between disease progression and telomere dynamics.
• We utilize the shortest telomere measurement of telomere length in tissue/cell samples from animals.

CD BioSciences specializes in research in the field of aging and longevity, based on research and technology development of telomere age clocks, mainly for the healthcare, and biotechnology industry. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Lai TP, et al. A method for measuring the distribution of the shortest telomeres in cells and tissues. Nature Communications, 2017, 8 (1):1356.