Telomerase is an RNA-protein complex; its main components are an RNA matrix for telomere synthesis (TERC), which also has a structural function, and reverse transcriptase (TERT). It plays a pivotal role in maintaining telomere length and cellular immortality. As the understanding of telomerase continues to expand, the development and application of telomerase activity assays have become increasingly important in aging research.
Fig .1 General functional scheme of the telomerase complex. (Skvortsov DA, et al., 2011)
At CD BioSciences, we take pride in our ability to offer high-quality services for telomerase activity assays in aging studies. Our focus on quality, precision, and innovation sets us apart in the field.
By adhering to stringent sample requirements and protocols, CD BioSciences ensures that clients receive accurate and reliable results in their telomerase activity assays, thereby contributing to the advancement of aging research and related studies.
CD BioSciences employs advanced methods for telomerase activity assays, driving precise and reproducible results for our clients. One of our key methodologies involves the telomere repeat amplification protocol (TRAP), a widely used technique that enables the detection and quantification of telomerase activity in various sample types. This approach, combined with advanced instrumentation and skilled technical expertise, allows us to offer a robust and detailed analysis of telomerase activity in aging studies.
| Methods | Telomerase Activity Assays |
| TRAP combined with enzyme-linked immunosorbent assay (ELISA) | We use TRAP for amplifying telomeric repeats, followed by the application of ELISA for the quantification of telomerase activity. Our method detects and measures the amplification products to provide a quantitative assessment of telomerase activity in the sample. |
| TRAP with electrochemical detection | We use electrochemical detection together with TRAP to accurately and specifically measure telomerase activity. Our method involves measuring the extension products generated by telomerase using electrochemical techniques. This allows us to determine telomerase activity levels in the sample with precision. |
| TRAP with real-time polymerase chain reaction (PCR) | Our method that combines TRAP with real-time PCR enables the real-time monitoring and quantification of amplified telomeric repeat sequences. As a result, we can assess telomerase activity dynamically and accurately. |
The assessment of telomerase activity through robust assays is integral to advancing our understanding of aging processes and associated pathologies. CD BioSciences offers exceptional services in telomerase activity assays, providing valuable insights into advances in aging research and the pursuit of healthier aging outcomes. If you are interested in our services, please feel free to contact us or make an online inquiry.
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