Y-27632, Dihydrochloride

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CAT. NO.: ABS-075

Product Details
Alternate Name	trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride
CAS Number	129830-38-2
Molecular Formula	C₁₄H₂₁N₃O.2HCl
Molecular Weight	320.26
Appearance	White soild
Purity	≥99% by HPLC
Solubility	H₂O (100 mM) or PBS (100 mM)
SMILES	CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
PubChem CID	9901617
Handling	Protect from air and moisture.
Storage Conditions	-20°C

Description
Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively. Prevents apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem cells (hES) without affecting their pluripotency.

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