XAV939

INQUIRY

CAT. NO.: ABS-074

Product Details
Alternate Name	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
CAS Number	284028-89-3
Molecular Formula	C₁₄H₁₁F₃N₂OS
Molecular Weight	312.31
Appearance	White solid
Purity	≥98% by HPLC
Solubility	DMSO (50 mM)
SMILES	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
PubChem CID	2726824
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
A Tankyrase (TNKS) inhibitor (IC50 = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.