IRS-2 Antibody

INQUIRY

CAT. NO.: AMA-0003

Target Information
UniProt ID	Q9Y4H2

Product Details
Size	20 μL/100 μL
Reactivity	Human, Mouse, Rat
Storage	Store at -20°C.
Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human IRS-2. Antibodies are purified by protein A and peptide affinity chromatography.

Usage
Application	WB
Product Usage Information Dilution	Western Blotting (1:1000)
MW (Target)	185 kDa

Background
Insulin Receptor Substrate 2 (IRS-2) is one of the major substrates of the insulin receptor kinase. In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades. IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults.

Background

Insulin Receptor Substrate 2 (IRS-2) is one of the major substrates of the insulin receptor kinase. In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades. IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults.

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