Ebselen

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CAT. NO.: ABA-012

Product Details
Alternate Name	2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
CAS Number	60940-34-3
Molecular Formula	C₁₃H₉NOSe
Molecular Weight	274.18
Appearance	White to off-white solid
Purity	≥99%
Solubility	DMSO (5 mg/mL)
SMILES	C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
PubChem CID	3194
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase (COX) and lipoxygenases at micromolar concentrations. Also acts as a histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1B protein with an IC50 of 5.17 µM.

Description

An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase (COX) and lipoxygenases at micromolar concentrations. Also acts as a histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1B protein with an IC50 of 5.17 µM.

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