Curcumin, Curcuma longa (High Purity)

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CAT. NO.: ABA-008

Product Details
Alternate Name	1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane
CAS Number	458-37-7
Molecular Formula	C₂₁H₂₀O₆
Molecular Weight	368.38
Appearance	Orange-yellow solid
Purity	≥98%
Solubility	DMSO (25 mg/mL) or EtOH (10 mg/mL)
SMILES	COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
PubChem CID	969516
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC50 = 8 µM) and cyclooxygenase (COX) (IC50 = 52 µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC50 of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).

Description

Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC50 = 8 µM) and cyclooxygenase (COX) (IC50 = 52 µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC50 of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).

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