Alexa647-labeled C-Rich telomere probe - 5 nmol

INQUIRY

CAT. NO.: AF003

Product Details
Kits Components	1 x 2mL tube containing 5 nmol of lyophilised probe
Sequence One Letter Code	repeats of CCCTAA
Absorbance (nm)	650
Emission (nm)	665
Modification Position	5'
Conjugation Type	Fluorescent dyes
Conjugation	Conjugated
Form	Dried
Resuspension Condition	Please refer to the protocol
Code Nacres	NA.51

Overview
The sequence of the Alexa 647-labeled C-rich telomere probe is constituted of CCCTAA repeats and is 5' labeled by the Alexa 647 fluorescent Dye. The sequence is specific for both human and mouse In principle, fluorescence in situ hybridisation (FISH) should be able to provide information on telomere length of individual chromosomes. However the efficiency of DNA/RNA oligonucleotide hybridizations for telomeric repeats investigation is not sufficient. In comparison the use of PNA stabilizes PNA-DNA/RNA duplexes. When used with PNA probes, PNA-DNA hybridization is much faster within a couple of hours and results in significantly reduced background noise due to the high signal to background noise ratio.

Overview

The sequence of the Alexa 647-labeled C-rich telomere probe is constituted of CCCTAA repeats and is 5' labeled by the Alexa 647 fluorescent Dye. The sequence is specific for both human and mouse
In principle, fluorescence in situ hybridisation (FISH) should be able to provide information on telomere length of individual chromosomes. However the efficiency of DNA/RNA oligonucleotide hybridizations for telomeric repeats investigation is not sufficient. In comparison the use of PNA stabilizes PNA-DNA/RNA duplexes. When used with PNA probes, PNA-DNA hybridization is much faster within a couple of hours and results in significantly reduced background noise due to the high signal to background noise ratio.

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