Torin 2

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CAT. NO.: ABM-020

Product Details
Alternate Name	9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
CAS Number	1223001-51-1
Molecular Formula	C₂₄H₁₅F₃N₄O
Molecular Weight	432.4
Appearance	Yellow solid
Purity	≥98% by HPLC
Solubility	DMSO (8 mg/mL)
SMILES	C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
PubChem CID	51358113
Handling	Protect from air and moisture.
Storage Conditions	-20°C

Description
A potent, selective and ATP-competitive mTOR inhibitor (IC50 = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to 440 other protein kinases.

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