Torin 1

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CAT. NO.: ABM-019

Product Details
Alternate Name	1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
CAS Number	1222998-36-8
Molecular Formula	C₃₅H₂₈F₃N₅O₂
Molecular Weight	607.62
Appearance	Slightly pinkish solid
Purity	≥98% by HPLC
Solubility	DMSO (2 mg/mL), N-methyl-2-pyrrolidone (25 mg/mL)
SMILES	CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
PubChem CID	49836027
Handling	Protect from air and moisture.
Storage Conditions	-20°C

Description
A potent, selective and ATP-competitive mTOR inhibitor, with IC50 values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.

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