5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate

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CAT. NO.: AF019

Product Details
Synonym(s)	5&6DH-DA, CDFDA, Carboxy-DCFDA
Empirical Formula (Hill Notation)	C₂₅H₁₄Cl₂O₉
CAS Number	127770-45-0
Molecular Weight	529.28
MDL Number	MFCD08459585
PubChem Substance ID	57647949
Size	100 mg
Assay	≥85% (HPCE)
Fluorescence	λ_ex 470 nm; λ_em 529 nm in 0.1 M Tris pH 8.0 (esterase)
Storage Temp.	-20°C
SMILES string	CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C4(OC(=O)c5cc(ccc45)C(O)=O)c2cc1Cl.CC(=O)Oc6cc7Oc8cc(OC(C)=O)c(Cl)cc8C9(OC(=O)c%10ccc(cc9%10)C(O)=O)c7cc6Cl

Description
5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate or CDFDA is a fluorescent oxidant sensing probe. It is an intracellular probe added to the cells as a pro-substrate, which upon hydrolysis by the esterase enzyme produces the fluorescent product called CDF.

Application
5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate or Carboxy-DCFDA is used as a cell permeate probe to detect intracellular reactive oxygen species (ROS). The anionic fluorescent dye, 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate is suitable for studying Multi-Drug Resistance (MDR) by target cells.

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