Fangchinoline

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CAT. NO.: ABA-013

Product Details
Alternate Name	Limacine; Frangchinoline; 7-O-Demethyltetrandine
CAS Number	436-77-1
Molecular Formula	C₃₇H₄₀N₂O₆
Molecular Weight	608.72
Appearance	Solid
Purity	≥98%
Solubility	25 mg/mL DMSO
SMILES	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC
PubChem CID	73481
Handling	Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions	-20°C

Description
Fangchinoline is a bisbenzylisoquinoline alkaloid that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to inhibit cell proliferation and cell cycle progression in rat aortic vascular smooth muscle cells. Fangchinoline inhibits apoptosis of osteoblasts and protects against bone loss in prednisolone-induced osteoporosis rats by inducing autophagy.

Description

Fangchinoline is a bisbenzylisoquinoline alkaloid that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to inhibit cell proliferation and cell cycle progression in rat aortic vascular smooth muscle cells. Fangchinoline inhibits apoptosis of osteoblasts and protects against bone loss in prednisolone-induced osteoporosis rats by inducing autophagy.

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