Atherosclerosis Drug Discovery Services

Atherosclerosis is a progressive disease characterized by the buildup of plaques, composed of fat, cholesterol, and other substances, within the walls of arteries. Increasing age is one of the strongest independent risk factors for developing atherosclerosis. As people age, the risk of plaque formation and arterial stiffness increases. The aging population is particularly susceptible to atherosclerosis due to various biological changes exacerbating its progression.

Fig. 1 Model of premature cellular senescence in atherosclerosis. (Wang JC, Bennett M, 2012)

CD BioSciences assists clients in discovering novel atherosclerosis drugs targeting aging-related vascular dysfunction, leveraging advanced research methodologies and extensive experience.

Atherosclerosis Drug Discovery Targeting Aging Mechanisms

Drug discovery targeting age-related endothelial dysfunction in atherosclerosis

Research has shown that restoring endothelial function can significantly impact atherosclerosis progression. We offer high-throughput screening services to help clients discover novel drugs that can enhance endothelial function, mitigating the effects of aging on blood vessel health. Our company also provides in vitro and in vivo models to identify whether these drugs restore endothelial function.

Drug discovery targeting age-related vascular remodeling in atherosclerosis

We help clients discover drugs that prevent detrimental vascular changes associated with aging. We provide advanced imaging and biomarker analysis services to determine whether drug candidates can inhibit excessive vascular smooth muscle cell proliferation and fibrosis, maintaining vascular integrity and reducing plaque formation.

Drug discovery targeting oxidative stress in atherosclerosis

Oxidative stress is a major contributor to aging and the progression of atherosclerosis. Our experts offer research services to identify potent antioxidants and other molecules that can mitigate oxidative damage and improve vascular function.

Drug discovery targeting age-associated mitochondrial dysfunction in atherosclerosis

We help clients identify and validate novel drugs targeting age-associated mitochondrial dysfunction to enhance energy metabolism and reduce cellular senescence in atherosclerosis. Our experts offer customized development solutions that focus on restoring mitochondrial function, addressing a fundamental aspect of cellular aging that impacts cardiovascular health.

Drug discovery targeting inflammaging in atherosclerosis

Senescent cells accumulate with age and secrete inflammatory cytokines that promote atherosclerosis. We help clients explore specific pathways and markers associated with cellular senescence and inflammation. We provide drug discovery services with a focus on developing drugs that selectively eliminate senescent cells.

Advantages of Our Atherosclerosis Drug Discovery Services

Advanced drug discovery platforms

Our drug discovery platforms integrate the latest advancements in high-throughput screening, computational biology, and precision medicine, empowering clients to rapidly identify and validate drug targets. Our advanced platforms facilitate rapid and accurate assessments, streamlining the drug discovery process.

Customized drug discovery solutions

We collaborate closely with clients to develop tailored strategies aligning with their specific research goals and therapeutic interests. We help clients develop customized experimental models that accurately reflect the biological processes of atherosclerosis. We adhere to stringent quality control measures throughout the research process, ensuring reliable and reproducible results.

CD BioSciences is dedicated to helping clients discover novel atherosclerosis drugs targeting the aging mechanisms. By targeting the fundamental processes involved in atherosclerosis, we aim to provide new therapeutic options. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Luo T, et al. Atherosclerosis treatment with nanoagents: potential targets, stimulus signals, and drug delivery mechanisms. Front Bioeng Biotechnol, 2023, 11: 1205751.
2. Tyrrell DJ, Goldstein DR. Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6. Nat Rev Cardiol, 2021, 18 (1): 58-68.
3. Wang JC, Bennett M. Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res, 2012, 111 (2): 245-59.