Aging increases the risk of age-related diseases, and the cost of medical care for aging can increase dramatically. Finding ways to slow or reverse aging to prevent age-related diseases has become more important. One novel therapy is the use of young molecules in the blood to reverse aging throughout the body, and CD BioSciences is working to help the biotechnology and biopharmaceutical industries discover ways to use these active molecules present in the blood to translate into therapies that reverse aging and treat related diseases.

Anti-Aging Effects of Young Blood

In an earlier study, researchers found that sharing blood with young and old rats could reverse aging in older rats. This novel finding sparked a series of studies on the reversal of aging by young blood, and many of the results suggest that plasma contains many biologically active molecules such as proteins that affect aging.

Table 1. Reported effects of blood-derived proteins that affect aging (Josephm C, 2018)

Proteins in plasma	Effects on Aging	Proteins in plasma	Effects on Aging
GHRH	Anti-aging	Oxytocin	Anti-aging
CCL11	Pro-aging	TIMP2	Anti-aging
B2M	Pro-aging	Osteocalcin	Anti-aging
GDF11	Anti-aging

The current approach includes both anti-aging and pro-aging approaches. One approach targets pro-aging molecules that affect aging, allowing the development of drugs such as neutralizing antibodies and molecular inhibitors that target aging-related molecules. The other approach is to discover and identify young proteins in plasma and explore the specific role of these active components in specific tissues or organs.

Anti-Aging Plasma Therapy Development

Blood products supply. Due to their inherent complexity, we need to ensure quality control, purification, active molecule extraction and other operations to maintain regenerative potential.

Protein-specific factor identification for anti-aging applications. Targeting multiple biological processes and multiple tissues, one or more active factors can be identified by identifying common pathways that can be used to limit the systemic effects of aging.

In vitro and in vivo validation of drug candidates. Animal model studies, multi-omics and multidisciplinary perspectives to assess aging phenotypes.

Challenges We Can Solve

• Biological models with higher relevance to humans, including short-lived models such as yeast, worms, and various rodent models.
• Objectives are achieved in a relatively short period of time, using a variety of computational and systems biology methods for high-volume screening in a comfortable and state-of-the-art experimental environment.
• The omics approach and multidisciplinary perspective expand the research space to enhance the development success rate.

Plasma therapies to reverse aging could reduce the concentration of some of the pro-aging proteins that rise with age while allowing for more anti-aging proteins. Some of these bioactive components are of particular interest and perhaps they will be included in our studies as drug candidates for aging-related diseases.

Are you interested in the project? Please contact us to set up a research team for you to immediately conduct exploratory trials to better understand how therapeutic plasma molecules can best be used to treat aging-related diseases.

References

1. Josephm C. Blood-Based Therapies to Combat Aging. Gerontology, 2018, 65:1-6.
2. Stevens M, et al. The Business of Anti-Aging Science. Trends in Biotechnology, 2017: S0167779917301713.

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