DNA Methylation Aging Clocks

Unique Technology

DNA Methylation Aging Clocks technology is an actual age estimator constructed from epigenetic DNA methylation marks. The unique high-throughput sequencing allows for low-cost and scalable targeted methylation sequencing, enabling high-performance age-related DNA methylation biomarker analysis, and the construction of epigenetic clocks to accurately predict age in many species. Automated library preparation enables researchers to process large volumes of samples in a short time, enabling low-cost investigations with flexible, reliable and scalable sequencing methods.

High Quality Technology for Aging Research, Disease Diagnosis

High throughput, low cost

Targeting highly age-associated loci to achieve broad biomarker identification with fewer sequencing reads

Scalable

Scalable from aging-related DNA methylation analysis to other DNA methylation biomarker analysis

Verified

Epigenetic clocks based on genomic DNA methylation are validated in a large sample of mice.

Powering Aging Research

DNA methylation clocks capture epigenetic modifications associated with aging and can indicate changes in the genome, cell biology, and tissues that occur over the course of life.

We clearly isolate the temporal and biological drivers of DNA methylation clocks, identify specific CpG sets for more robust dedicated clocks and study different mechanisms.

Search for age-specific disease and tissue-specific DNA molecular markers for individual tissues, with custom clocks for disease-specific analysis that can lead to unique pathophysiological insights.

We actively explore other DNA modifications, as well as chromatin modifications, and may reveal promising age-related properties that can be integrated into individual aging models.

Development and use of single cell analysis techniques to precisely explore core epigenomic questions related to cell specificity and tissue specificity with age.

Application Prospects

Aging Exploration

We can precisely show DNA methylation associated with aging.

Detailed assessment of DNA methylation clocks can reveal unique insights into the aging process itself, as well as serve as biomarkers of biological age and inform the risk of common diseases associated with biological actual age.

Therapy Development

We believe DNA methylation age clock technology has the potential to be a robust and sensitive assessment system that can help accelerate the development and production of biologics for age-related diseases.

It allows rapid scale-up to identify specific DNA methylation biomarkers for different disease types for developing therapeutic agents and evaluating drug performance.

Reference

Bell, C G, et al. DNA methylation aging clocks: challenges and recommendations. Genome Biol, 2019, 20(249).

Let's start opening up the future of aging research with the DNA methylation clock !

To work with us or to learn more about our DNA methylation clock technology, please contact us.