Customization of Aging Animal Models

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The study of the molecular basis of the aging process and the development of anti-aging therapies has become an emerging area of research in recent years. CD BioSciences recognizes the importance of this emerging field and has developed a series of animal models for aging research. We utilize a variety of model organisms for the construction of various age-related disease models and aging models.

Our Services

We are committed to providing you with high-quality animal models for aging research. From genetic standards and disease-specific models to surgically modified animals, you can rely on us completely. It is critical to the success of your research that you select or directly customize a more appropriate animal model for your study.

You can read below how to customize an animal model to meet your research needs.

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Primitive Organism Models
We often use the yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster as ideal models for aging studies. We take full advantage of the short lifespan and longevity-related genes of these model organisms, tailored as valuable animal models for studying aging.

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NHP Models
HNPs have a close phylogenetic relationship with humans, and therefore we are using a number of NHP models in age-related disease studies. We can provide custom services for some primate models such as rhesus, squirrel monkeys, and common marmosets. These models can be used for aging and longevity experiments.

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Small Rodent Models
Mice and rats are often the animal models of choice for aging studies. Their relatively small body size and short lifespan make them easier to study. We can create a variety of mouse gene lines that mimic diseases associated with aging through targeted genetic manipulation. All of these mouse models can help scientists provide new insights into the mechanisms of aging.

Available Models of Common Age-Related Diseases

  • Bone disease. For example, age-related bone loss, and age-related osteoporosis models.
  • Cardiovascular diseases. For example, the primary hypertension animal model, myocardial infarction animal model, heart failure animal model, etc.
  • Aging lung.
  • Neurodegenerative disease. For example, models of Parkinson's disease and Alzheimer's disease.
  • Multi-morbidity and frailty. For example, some chronic disease models include arthritis, diabetes, cancer, heart disease, and stroke. There are also frailty animal models.

Ready to Custom Aging Models

  • Start with the right genetic background. No matter what genetic background you choose, our genetically stable, germline-competent animal models will meet your needs.
  • Use the right strategy. We offer free consultations to assess the feasibility of your new model. Our technical experts use a variety of model-generation techniques to generate new aging models.
  • Get the animal model you need. We can ship your custom aging model directly to your facility. You can use these risk-free animal models with confidence.

CD BioSciences is ready to provide assistance with model customization. Our team will work with you to find the best strategy for generating new aging animal models to support your drug discovery pipeline.

Contact us today to learn more about our custom aging research models, or to discuss your project with us.

Reference

  1. Santulli G, et al. Models for preclinical studies in aging-related disorders: One is not for all. Transl Med UniSa, 2016, 13: 4-12.

Our services are for research use only and not for any clinical use.

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